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提交成功！From Wikipedia, the free encyclopedia
Identifiers
, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
External IDs
Gene location (Human)
100,238,298
100,282,792
Gene location (Mouse)
Chromosome 12 (mouse)
12 F1|12 59.58 cM
108,792,973
108,820,148
Molecular function
Cellular component
Biological process
Sources: /
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)
YY1 (Yin Yang 1) is a transcriptional repressor
in humans that is encoded by the YY1 .
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. Hence, the YY in the name stands for "." YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1.
YY1 has been shown to
- , May 2017
- , May 2017
Thiaville MM, Kim J (2011). . Critical Reviews in Oncogenesis. 16 (3–4): 199–209. :.   .  .
Shi Y, Seto E, Chang LS, Shenk T (Oct 1991). "Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein". Cell. 67 (2): 377–88. :.  .
Zhu W, Lossie AC, Camper SA, Gumucio DL (Apr 1994). "Chromosomal localization of the transcription factor YY1 in the mouse and human". Mammalian Genome. 5 (4): 234–6. :.  .
Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS (Jul 2000). . Molecular and Cellular Biology. 20 (14): . :.   .  .
Yao YL, Yang WM, Seto E (Sep 2001). . Molecular and Cellular Biology. 21 (17): 5979–91. :.   .  .
Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. :.  .
Yang WM, Yao YL, Seto E (Sep 2001). . The EMBO Journal. 20 (17): 4814–25. :.   .  .
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (Oct 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. :.  .
Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Feb 1997). . Nucleic Acids Research. 25 (4): 843–9. :.   .  .
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. :.  .
Yeh TS, Lin YM, Hsieh RH, Tseng MJ (Oct 2003). "Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch". The Journal of Biological Chemistry. 278 (43): 41963–9. :.  .
García E, Marcos-Gutiérrez C, del Mar Lorente M, Moreno JC, Vidal M (Jun 1999). . The EMBO Journal. 18 (12): 3404–18. :.   .  .
Huang NE, Lin CH, Lin YS, Yu WC (Jun 2003). "Modulation of YY1 activity by SAP30". Biochemical and Biophysical Research Communications. 306 (1): 267–75. :.  .
Fu CY, Wang P, Tsai HJ (Nov 2017). "Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis". Nucleic Acids Research. 45 (5): . :.
Thomas MJ, Seto E (Aug 1999). "Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?". Gene. 236 (2): 197–208. :.  .
Park K, Atchison ML (Nov 1991). . Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9804–8. :.   .  .
Yang WM, Inouye CJ, Seto E (Jun 1995). "Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity". The Journal of Biological Chemistry. 270 (25): 15187–93. :.  .
Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). "Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300". Genes & Development. 9 (10): 1188–98. :.  .
Zhou Q, Gedrich RW, Engel DA (Jul 1995). . Journal of Virology. 69 (7): 4323–30.   .  .
Shrivastava A, Saleque S, Kalpana GV, Artandi S, Goff SP, Calame K (Dec 1993). "Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc". Science. 262 (5141): 1889–92. :.  .
Becker KG, Swergold GD, Ozato K, Thayer RE (Oct 1993). "Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element". Human Molecular Genetics. 2 (10): . :.  .
Margolis DM, Somasundaran M, Green MR (Feb 1994). . Journal of Virology. 68 (2): 905–10.   .  .
Lee JS, Galvin KM, Shi Y (Jul 1993). . Proceedings of the National Academy of Sciences of the United States of America. 90 (13): 6145–9. :.   .  .
Yang WM, Inouye C, Zeng Y, Bearss D, Seto E (Nov 1996). . Proceedings of the National Academy of Sciences of the United States of America. 93 (23): 12845–50. :.   .  .
Houbaviy HB, Usheva A, Shenk T, Burley SK (Nov 1996). . Proceedings of the National Academy of Sciences of the United States of America. 93 (24): 13577–82. :.   .  .
Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Feb 1997). . Nucleic Acids Research. 25 (4): 843–9. :.   .  .
Cole EG, Gaston K (Sep 1997). . Nucleic Acids Research. 25 (18): 3705–11. :.   .  .
Yang WM, Yao YL, Sun JM, Davie JR, Seto E (Oct 1997). "Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family". The Journal of Biological Chemistry. 272 (44): 28001–7. :.  .
Romerio F, Gabriel MN, Margolis DM (Dec 1997). . Journal of Virology. 71 (12): 9375–82.   .  .
McNeil S, Guo B, Stein JL, Lian JB, Bushmeyer S, Seto E, Atchison ML, Penman S, van Wijnen AJ, Stein GS (Mar 1998). "Targeting of the YY1 transcription factor to the nucleolus and the nuclear matrix in situ: the C-terminus is a principal determinant for nuclear trafficking". Journal of Cellular Biochemistry. 68 (4): 500–10. :.  .
Viles JH, Patel SU, Mitchell JB, Moody CM, Justice DE, Uppenbrink J, Doyle PM, Harris CJ, Sadler PJ, Thornton JM (Jun 1998). "Design, synthesis and structure of a zinc finger with an artificial beta-turn". Journal of Molecular Biology. 279 (4): 973–86. :.  .
Yao YL, Dupont BR, Ghosh S, Fang Y, Leach RJ, Seto E (Aug 1998). . Nucleic Acids Research. 26 (16): 3776–83. :.   .  .
PDB gallery
1ubd: CO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT 
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