propan-2-ol 异丙醇是酒精吗 是酒精吗
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异丙醇，俗称火酒，常温常压下是一种无色有强烈气味的可燃液体，分子式为C3H8O。异丙醇是最简单的仲醇，且是丙醇异构体之一，CAS号为67-63-0 。
中文名称：
中文别名：
二甲基甲醇;
2-羟基丙烷;
英文名称：
propan-2-ol
英文别名：
精确质量：
危险化学品
外观与性状：
0.785&g/mL&at 25&&C(lit.)
82&&C(lit.)
n20/D 1.377(lit.)
水溶解性：
储存条件：
库房通风低温干燥,与氧化剂、酸类分开存放
33 mm Hg ( 20 &C)
蒸汽密度：
2.1 (vs air)
信号词：危险
危害声明：
警示性声明：
包装等级：II
危险类别：3
海关编码：
危险品运输编码：UN 1219 3/PG 2
WGK Germany：1
危险类别码：R11; R36; R67; R40; R10; R36/38
安全说明：S7-S16-S24/25-S26-S36/37
RTECS号：NT8050000
危险品标志：F
异丙醇是重要的化工产品和原料。主要用于制药、化妆品、塑料、香料、涂料等。
(dipicolinate)VV(O)(OiPr)
总计：1812
-氯-5-甲氧基-6-甲基苯并[b]噻吩-2-羧酸异丙酯
N-phenyl-N-propan-2-ylnaphthalen-1-amine
3-苯基-2-丙烯酸-1-甲乙酯
propan-2-yl 2-oxo-4-phenylbut-3-enoate
(3-ethoxy-2-phenyl-3-propan-2-yloxycyclopropen-1-yl)benzene
2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：接触高浓度蒸气出现头痛、倦睡、共济失调以及眼、鼻、喉刺激症状。口服可致恶心、呕吐、腹痛、腹泻、倦睡、昏迷甚至死亡。长期皮肤接触可致皮肤干燥、皲裂。
二、毒理学资料及环境行为
毒性：属微毒类。
急性毒性：LD505045mg/kg(大鼠经口)；12800mg/kg(兔经皮)；人吸入980mg/m3×3～5分钟，眼鼻粘膜轻度刺激；人经口22.5ml头晕、面红，吸入2～3小时后头痛、恶心。亚急性和慢性毒性：大鼠吸入1.0ppm×24小时/日×3个月，肝、肾功能异常；大鼠吸入8.4ppm×24小时/日×3个月，肝、肾严重损害。
致突变性：细胞遗传学分析：制酒酵母菌200mmol/管。致癌性：小鼠吸入3000ppm×3～7小时/日×5日/周×5～8月肿瘤发病率增高。
危险特性：易燃，其蒸气与空气可形成爆炸性混合物。遇明火、高热能引起燃烧爆炸。与氧化剂接触会猛烈反应。在火场中，受热的容器有爆炸危险。其蒸气比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。燃烧(分解)产物：一氧化碳、二氧化碳。
3.现场应急监测方法:
气体检测管法
4.实验室监测方法:
气相色谱法《空气中有害物质的测定方法》(第二版)，杭士平主编
5.环境标准:
0.6mg/m3(最大值、昼夜均值)
6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿消防防护服。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。也可以用大量水冲洗，洗液稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内。回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：空气中浓度超标时，应该佩戴过滤式防毒面罩(半面罩)。
眼睛防护：一般不需要特殊防护，高浓度接触时可戴化学安全防护眼镜。
身体防护：穿防静电工作服。
手防护：戴乳胶手套。
其它：工作现场严禁吸烟。保持良好的卫生习惯。
三、急救措施
皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。 眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。就医。 吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即
进行人工呼吸。就医。 食入：洗胃。就医。
灭火方法：尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。灭火剂：抗溶性泡沫、干粉、二氧化碳、砂土。
中国海关编码：
1H NMR : in CD3CN
1H NMR : in CD3CN
Assign.     Shift(ppm)      A          3.868     B          2.571     C          1.095     Assigned with HMQC and HMBC.The part of residual     water peak was removed from this spectrum. 
1H NMR : in CD3OD
1H NMR : in CD3OD
Assign.     Shift(ppm)      A           4.81     B          3.921     C          1.149     Peak A overlapped to the solvent peak. 
13C NMR : in CDCl3
13C NMR : in CDCl3
ppm   Int.  Assign.        64.04   732      1       25.29  1000      2 
13C NMR : in DMSO-d6
13C NMR : in DMSO-d6
ppm   Int.  Assign.         61.95   364     1                25.40  1000     2             Assigned with HMBC. 
13C NMR : in CDCl3
13C NMR : in CDCl3
ppm   Int.  Assign.         64.40   266     1                25.36  1000     2 
13C NMR : in CD3CN
13C NMR : in CD3CN
ppm   Int.  Assign.         64.08   251     1                25.56  1000     2             Assigned with HMQC and HMBC. 
13C NMR : in CD3OD
13C NMR : in CD3OD
ppm   Int.  Assign.         64.77   308     1                25.30  1000     2 
1H NMR : 90 MHz in CDCl3
1H NMR : 90 MHz in CDCl3
Assign.     Shift(ppm)       A             4.008      B             2.16      C             1.200 
1H NMR : in DMSO-d6
1H NMR : in DMSO-d6
Assign.     Shift(ppm)      A          4.324     B          3.777     C          1.041     Assigned with HMBC.The part of residual water peak     was removed from this spectrum. 
1H NMR : in CDCl3
1H NMR : in CDCl3
Assign.     Shift(ppm)      A          4.021     B          1.632     C          1.206 
Predict 1H proton NMR
Predict 1H proton NMR
13C NMR : Predict
13C NMR : Predict
1H NMR : Predict
1H NMR : Predict
红外图谱(IR)
IR : liquid film
IR : liquid film
质谱(MS/Mass)
Source Temperature: 240 °C   Sample Temperature: 180 °C   RESERVOIR, 75 eV
拉曼光谱(Raman)
Raman : 4880 A,150M,liquid
Raman : 4880 A,150M,liquid
电子自旋光谱(ESR)
ESR : OXIDATION WITH TI(III)/H2O2
ESR : OXIDATION WITH TI(III)/H2O2
Sample Preparation:     OXIDATION OF ISOPROPYL ALCOHOL WITH TI(III)/H2O2(FLOW SYSTEM )ESR Spectral Parameters:  Splitting Constant        A(6H,CH3)              20.0     GMeasuring Conditions:    Medium and Temperature  ISOPROPANOL, H2O2, TI, H2SO4, RTSource:   W.T.DIXON ET AL,J.CHEM.SOC.,63) / OP3121, FIG.5
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 4K
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 4K
Sample Preparation:     UV IRRADIATION OF MIXTURE OF ACETONE AND ISOPROPANOLESR Spectral Parameters:     G(AVERAGE)                2.003  Splitting Constant        A(6H,CH3)              20.      GMeasuring Conditions:    Medium and Temperature  ACETONE, 4K    Microwave Frequency    X-BANDSource:   A.KATAYAMA ET AL,CHEM.LETT.,199-202(1975) / PP202, FIG.3
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 77K
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 77K
Sample Preparation:     UV IRRADIATION OF MIXTURE OF ACETONE AND ISOPROPANOLESR Spectral Parameters:     G(AVERAGE)                2.003  Splitting Constant        A(6H,CH3)              20.      GMeasuring Conditions:    Medium and Temperature  ACETONE, 77K    Microwave Frequency    X-BANDSource:   A.KATAYAMA ET AL,CHEM.LETT.,199-202(1975) / PP201, FIG.2
更多异丙醇图谱参考资料
CHEMICAL IDENTIFICATIONRTECS NUMBER :NT8050000CHEMICAL NAME :Isopropyl alcoholCAS REGISTRY NUMBER :67-63-0BEILSTEIN REFERENCE NO. :0635639LAST UPDATED :199712DATA ITEMS CITED :90MOLECULAR FORMULA :C3-H8-OMOLECULAR WEIGHT :60.11WISWESSER LINE NOTATION :QY1&1HEALTH HAZARD DATAACUTE TOXICITY DATATYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration onto the skinSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - manDOSE/DURATION :14432 mg/kgTOXIC EFFECTS :Behavioral - coma
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspneaTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :HumanDOSE/DURATION :223 mg/kgTOXIC EFFECTS :Behavioral - hallucinations, distorted perceptions
Cardiac - pulse rate
Vascular - BP lowering not characterized in autonomic sectionTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - manDOSE/DURATION :5272 mg/kgTOXIC EFFECTS :Behavioral - coma
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - chronic pulmonary edemaTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :HumanDOSE/DURATION :3570 mg/kgTOXIC EFFECTS :Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - nausea or vomitingTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - infantDOSE/DURATION :13 gm/kgTOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Behavioral - irritability
Gastrointestinal - nausea or vomitingTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :UnreportedSPECIES OBSERVED :Human - manDOSE/DURATION :2770 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :UnreportedSPECIES OBSERVED :Human - infantDOSE/DURATION :1375 mg/kgTOXIC EFFECTS :Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptionsTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - ratDOSE/DURATION :5045 mg/kgTOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LC50 - Lethal concentration, 50 percent killROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :16000 ppm/8HTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - ratDOSE/DURATION :2735 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - ratDOSE/DURATION :1088 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :3600 mg/kgTOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LCLo - Lowest published lethal concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :12800 ppm/3HTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :4477 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :SubcutaneousSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :6 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :1509 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Mammal - dogDOSE/DURATION :1537 mg/kgTOXIC EFFECTS :Gastrointestinal - nausea or vomitingTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Mammal - dogDOSE/DURATION :1024 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Mammal - catDOSE/DURATION :6 mL/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Mammal - catDOSE/DURATION :1963 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :6410 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :Administration onto the skinSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :12800 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :667 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :1184 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - guinea pigDOSE/DURATION :2560 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - hamsterDOSE/DURATION :3444 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :ParenteralSPECIES OBSERVED :Amphibian - frogDOSE/DURATION :20 gm/kgTOXIC EFFECTS :Peripheral Nerve and Sensation - spastic paralysis with or without sensory
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :SubcutaneousSPECIES OBSERVED :Mammal - species unspecifiedDOSE/DURATION :6 gm/kgTOXIC EFFECTS :Peripheral Nerve and Sensation - spastic paralysis with or without sensory
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - other changesTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - ratDOSE/DURATION :7 mL/kg/7D-ITOXIC EFFECTS :Liver - other changes
Biochemical - Effect on specific coenzyme - B vitamins including folateTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :100 mg/m3/4H/17W-ITOXIC EFFECTS :Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesteraseTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :8000 ppm/8H/20W-ITOXIC EFFECTS :Peripheral Nerve and Sensation - sensory change involving peripheral nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerveTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :5000 ppm/6H/90D-ITOXIC EFFECTS :Behavioral - changes in motor activity (specific assay)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :2500 ppm/6H/2Y-ITOXIC EFFECTS :Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weightTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :10000 ppm/6H/11D-ITOXIC EFFECTS :Behavioral - general anesthetic
Behavioral - ataxia
Related to Chronic Data - deathTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/13W-ITOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cellsTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/13W-ITOXIC EFFECTS :Behavioral - general anesthetic
Behavioral - ataxia
Liver - changes in liver weightTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/78W-ITOXIC EFFECTS :Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :11340 mg/kgSEX/DURATION :female 45 day(s) pre-matingTOXIC EFFECTS :Reproductive - Maternal Effects - menstrual cycle changes or disordersTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :5040 mg/kgSEX/DURATION :female 1-20 day(s) after conceptionTOXIC EFFECTS :Reproductive - Fertility - litter size (e.g. # measured
before birth)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :8 gm/kgSEX/DURATION :female 6-15 day(s) after conceptionTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :32400 ug/kgSEX/DURATION :female 26 week(s) pre-matingTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetal deathTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :3500 gm/kgSEX/DURATION :multigenerationTOXIC EFFECTS :Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # # copulations per # estrus cycles)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :3500 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :10000 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal deathTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :7000 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Specific Developmental Abnormalities - musculoskeletal systemTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :6240 mg/kgSEX/DURATION :female 6-18 day(s) after conceptionTOXIC EFFECTS :Reproductive - Maternal Effects - other effectsMUTATION DATATEST SYSTEM :Rodent - ratREFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.
Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, . For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),33,1981
*** REVIEWS ***
ACGIH TLV-STEL 1230 mg/m3 (500 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 983 mg/m3 (400 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
(WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year: 15,223,1977
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement.
(WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year:
7,229,1987
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement.
(WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year:
7,229,1987
TOXICOLOGY REVIEW
JIHTAB Journal of Industrial Hygiene and Toxicology.
(Cambridge, MA)
V.18-31, 1936-49.
For publisher information, see AEHLAU.
Volume(issue)/page/year: 20,428,1938
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC).
(American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006)
Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register.
(U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1-
Volume(issue)/page/year:
MSHA STANDARD-air:TWA 400 ppm (980 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
3,141,1971
OSHA PEL (Gen Indu):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 400 ppm (980 mg/m3);STEL 500 ppm (1225 mg/m3) JAN 1993
OEL-BELGIUM:TWA 400 ppm (985 mg/m3);STEL 500 ppm (1230 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (490 mg/m3);Skin JAN 1993
OEL-FRANCE:STEL 400 ppm (980 mg/m3) JAN 1993
OEL-GERMANY:TWA 400 ppm (980 mg/m3) JAN 1993
OEL-JAPAN:STEL 400 ppm (980 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 400 ppm (980 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 400 ppm (980 mg/m3) JAN 1993
OEL-RUSSIA:STEL 400 ppm (10 mg/m3) JAN 1993
OEL-SWEDEN:TWA 150 ppm (350 mg/m3);STEL 250 ppm (600 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 400 ppm (980 mg/m3);STEL 800 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (500 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 400 ppm (980 mg/m3);STEL 500Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ISOPROPYL ALCOHOL-air:10H TWA 400STEL 500 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 40987
No. of Facilities: 213605 (estimated)
No. of Industries: 465
No. of Occupations: 252
No. of Employees: 3183554 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 40987
No. of Facilities: 183402 (estimated)
No. of Industries: 449
No. of Occupations: 278
No. of Employees: 4665524 (estimated)
No. of Female Employees: 2058264 (estimated)
更多该化合物百科信息
其它您可能感兴趣的化合物
甲酸异丙酯
2-[2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methylpyran-4-ylidene]propanedinitrile
钛酸四异丙酯
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您可能还感兴趣的信息异丙醇_异丙醇CAS号67-63-0,异丙醇说明/性质/作用/用途–摩贝百科
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异丙醇，俗称火酒，常温常压下是一种无色有强烈气味的可燃液体，分子式为C3H8O。异丙醇是最简单的仲醇，且是丙醇异构体之一，CAS号为67-63-0 。
中文名称：
中文别名：
二甲基甲醇;
2-羟基丙烷;
英文名称：
propan-2-ol
英文别名：
精确质量：
危险化学品
外观与性状：
0.785&g/mL&at 25&&C(lit.)
82&&C(lit.)
n20/D 1.377(lit.)
水溶解性：
储存条件：
库房通风低温干燥,与氧化剂、酸类分开存放
33 mm Hg ( 20 &C)
蒸汽密度：
2.1 (vs air)
信号词：危险
危害声明：
警示性声明：
包装等级：II
危险类别：3
海关编码：
危险品运输编码：UN 1219 3/PG 2
WGK Germany：1
危险类别码：R11; R36; R67; R40; R10; R36/38
安全说明：S7-S16-S24/25-S26-S36/37
RTECS号：NT8050000
危险品标志：F
异丙醇是重要的化工产品和原料。主要用于制药、化妆品、塑料、香料、涂料等。
(dipicolinate)VV(O)(OiPr)
总计：1812
-氯-5-甲氧基-6-甲基苯并[b]噻吩-2-羧酸异丙酯
N-phenyl-N-propan-2-ylnaphthalen-1-amine
3-苯基-2-丙烯酸-1-甲乙酯
propan-2-yl 2-oxo-4-phenylbut-3-enoate
(3-ethoxy-2-phenyl-3-propan-2-yloxycyclopropen-1-yl)benzene
2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：接触高浓度蒸气出现头痛、倦睡、共济失调以及眼、鼻、喉刺激症状。口服可致恶心、呕吐、腹痛、腹泻、倦睡、昏迷甚至死亡。长期皮肤接触可致皮肤干燥、皲裂。
二、毒理学资料及环境行为
毒性：属微毒类。
急性毒性：LD505045mg/kg(大鼠经口)；12800mg/kg(兔经皮)；人吸入980mg/m3×3～5分钟，眼鼻粘膜轻度刺激；人经口22.5ml头晕、面红，吸入2～3小时后头痛、恶心。亚急性和慢性毒性：大鼠吸入1.0ppm×24小时/日×3个月，肝、肾功能异常；大鼠吸入8.4ppm×24小时/日×3个月，肝、肾严重损害。
致突变性：细胞遗传学分析：制酒酵母菌200mmol/管。致癌性：小鼠吸入3000ppm×3～7小时/日×5日/周×5～8月肿瘤发病率增高。
危险特性：易燃，其蒸气与空气可形成爆炸性混合物。遇明火、高热能引起燃烧爆炸。与氧化剂接触会猛烈反应。在火场中，受热的容器有爆炸危险。其蒸气比空气重，能在较低处扩散到相当远的地方，遇明火会引着回燃。燃烧(分解)产物：一氧化碳、二氧化碳。
3.现场应急监测方法:
气体检测管法
4.实验室监测方法:
气相色谱法《空气中有害物质的测定方法》(第二版)，杭士平主编
5.环境标准:
0.6mg/m3(最大值、昼夜均值)
6.应急处理处置方法:
一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿消防防护服。尽可能切断泄漏源，防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。也可以用大量水冲洗，洗液稀释后放入废水系统。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用防爆泵转移至槽车或专用收集器内。回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：空气中浓度超标时，应该佩戴过滤式防毒面罩(半面罩)。
眼睛防护：一般不需要特殊防护，高浓度接触时可戴化学安全防护眼镜。
身体防护：穿防静电工作服。
手防护：戴乳胶手套。
其它：工作现场严禁吸烟。保持良好的卫生习惯。
三、急救措施
皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤。 眼睛接触：提起眼睑，用流动清水或生理盐水冲洗。就医。 吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即
进行人工呼吸。就医。 食入：洗胃。就医。
灭火方法：尽可能将容器从火场移至空旷处。喷水保持火场容器冷却，直至灭火结束。处在火场中的容器若已变色或从安全泄压装置中产生声音，必须马上撤离。灭火剂：抗溶性泡沫、干粉、二氧化碳、砂土。
中国海关编码：
1H NMR : in CD3CN
1H NMR : in CD3CN
Assign.     Shift(ppm)      A          3.868     B          2.571     C          1.095     Assigned with HMQC and HMBC.The part of residual     water peak was removed from this spectrum. 
1H NMR : in CD3OD
1H NMR : in CD3OD
Assign.     Shift(ppm)      A           4.81     B          3.921     C          1.149     Peak A overlapped to the solvent peak. 
13C NMR : in CDCl3
13C NMR : in CDCl3
ppm   Int.  Assign.        64.04   732      1       25.29  1000      2 
13C NMR : in DMSO-d6
13C NMR : in DMSO-d6
ppm   Int.  Assign.         61.95   364     1                25.40  1000     2             Assigned with HMBC. 
13C NMR : in CDCl3
13C NMR : in CDCl3
ppm   Int.  Assign.         64.40   266     1                25.36  1000     2 
13C NMR : in CD3CN
13C NMR : in CD3CN
ppm   Int.  Assign.         64.08   251     1                25.56  1000     2             Assigned with HMQC and HMBC. 
13C NMR : in CD3OD
13C NMR : in CD3OD
ppm   Int.  Assign.         64.77   308     1                25.30  1000     2 
1H NMR : 90 MHz in CDCl3
1H NMR : 90 MHz in CDCl3
Assign.     Shift(ppm)       A             4.008      B             2.16      C             1.200 
1H NMR : in DMSO-d6
1H NMR : in DMSO-d6
Assign.     Shift(ppm)      A          4.324     B          3.777     C          1.041     Assigned with HMBC.The part of residual water peak     was removed from this spectrum. 
1H NMR : in CDCl3
1H NMR : in CDCl3
Assign.     Shift(ppm)      A          4.021     B          1.632     C          1.206 
Predict 1H proton NMR
Predict 1H proton NMR
13C NMR : Predict
13C NMR : Predict
1H NMR : Predict
1H NMR : Predict
红外图谱(IR)
IR : liquid film
IR : liquid film
质谱(MS/Mass)
Source Temperature: 240 °C   Sample Temperature: 180 °C   RESERVOIR, 75 eV
拉曼光谱(Raman)
Raman : 4880 A,150M,liquid
Raman : 4880 A,150M,liquid
电子自旋光谱(ESR)
ESR : OXIDATION WITH TI(III)/H2O2
ESR : OXIDATION WITH TI(III)/H2O2
Sample Preparation:     OXIDATION OF ISOPROPYL ALCOHOL WITH TI(III)/H2O2(FLOW SYSTEM )ESR Spectral Parameters:  Splitting Constant        A(6H,CH3)              20.0     GMeasuring Conditions:    Medium and Temperature  ISOPROPANOL, H2O2, TI, H2SO4, RTSource:   W.T.DIXON ET AL,J.CHEM.SOC.,63) / OP3121, FIG.5
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 4K
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 4K
Sample Preparation:     UV IRRADIATION OF MIXTURE OF ACETONE AND ISOPROPANOLESR Spectral Parameters:     G(AVERAGE)                2.003  Splitting Constant        A(6H,CH3)              20.      GMeasuring Conditions:    Medium and Temperature  ACETONE, 4K    Microwave Frequency    X-BANDSource:   A.KATAYAMA ET AL,CHEM.LETT.,199-202(1975) / PP202, FIG.3
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 77K
ESR : UV IRRAD. OF ACETONE AND ISOPROPANOL AT 77K
Sample Preparation:     UV IRRADIATION OF MIXTURE OF ACETONE AND ISOPROPANOLESR Spectral Parameters:     G(AVERAGE)                2.003  Splitting Constant        A(6H,CH3)              20.      GMeasuring Conditions:    Medium and Temperature  ACETONE, 77K    Microwave Frequency    X-BANDSource:   A.KATAYAMA ET AL,CHEM.LETT.,199-202(1975) / PP201, FIG.2
更多异丙醇图谱参考资料
CHEMICAL IDENTIFICATIONRTECS NUMBER :NT8050000CHEMICAL NAME :Isopropyl alcoholCAS REGISTRY NUMBER :67-63-0BEILSTEIN REFERENCE NO. :0635639LAST UPDATED :199712DATA ITEMS CITED :90MOLECULAR FORMULA :C3-H8-OMOLECULAR WEIGHT :60.11WISWESSER LINE NOTATION :QY1&1HEALTH HAZARD DATAACUTE TOXICITY DATATYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration onto the skinSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :Standard Draize testROUTE OF EXPOSURE :Administration into the eyeSPECIES OBSERVED :Rodent - rabbitTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - manDOSE/DURATION :14432 mg/kgTOXIC EFFECTS :Behavioral - coma
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - dyspneaTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :HumanDOSE/DURATION :223 mg/kgTOXIC EFFECTS :Behavioral - hallucinations, distorted perceptions
Cardiac - pulse rate
Vascular - BP lowering not characterized in autonomic sectionTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - manDOSE/DURATION :5272 mg/kgTOXIC EFFECTS :Behavioral - coma
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - chronic pulmonary edemaTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :HumanDOSE/DURATION :3570 mg/kgTOXIC EFFECTS :Behavioral - coma
Lungs, Thorax, or Respiration - respiratory depression
Gastrointestinal - nausea or vomitingTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Human - infantDOSE/DURATION :13 gm/kgTOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Behavioral - irritability
Gastrointestinal - nausea or vomitingTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :UnreportedSPECIES OBSERVED :Human - manDOSE/DURATION :2770 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :UnreportedSPECIES OBSERVED :Human - infantDOSE/DURATION :1375 mg/kgTOXIC EFFECTS :Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Behavioral - somnolence (general depressed activity)
Behavioral - hallucinations, distorted perceptionsTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - ratDOSE/DURATION :5045 mg/kgTOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LC50 - Lethal concentration, 50 percent killROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :16000 ppm/8HTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - ratDOSE/DURATION :2735 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - ratDOSE/DURATION :1088 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :3600 mg/kgTOXIC EFFECTS :Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LCLo - Lowest published lethal concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :12800 ppm/3HTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :4477 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :SubcutaneousSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :6 gm/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :1509 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Mammal - dogDOSE/DURATION :1537 mg/kgTOXIC EFFECTS :Gastrointestinal - nausea or vomitingTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Mammal - dogDOSE/DURATION :1024 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Mammal - catDOSE/DURATION :6 mL/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Mammal - catDOSE/DURATION :1963 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :6410 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :Administration onto the skinSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :12800 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :667 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntravenousSPECIES OBSERVED :Rodent - rabbitDOSE/DURATION :1184 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - guinea pigDOSE/DURATION :2560 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LD50 - Lethal dose, 50 percent killROUTE OF EXPOSURE :IntraperitonealSPECIES OBSERVED :Rodent - hamsterDOSE/DURATION :3444 mg/kgTOXIC EFFECTS :Details of toxic effects not reported other than lethal dose valueTYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :ParenteralSPECIES OBSERVED :Amphibian - frogDOSE/DURATION :20 gm/kgTOXIC EFFECTS :Peripheral Nerve and Sensation - spastic paralysis with or without sensory
Behavioral - somnolence (general depressed activity)TYPE OF TEST :LDLo - Lowest published lethal doseROUTE OF EXPOSURE :SubcutaneousSPECIES OBSERVED :Mammal - species unspecifiedDOSE/DURATION :6 gm/kgTOXIC EFFECTS :Peripheral Nerve and Sensation - spastic paralysis with or without sensory
Behavioral - general anesthetic
Lungs, Thorax, or Respiration - other changesTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralSPECIES OBSERVED :Rodent - ratDOSE/DURATION :7 mL/kg/7D-ITOXIC EFFECTS :Liver - other changes
Biochemical - Effect on specific coenzyme - B vitamins including folateTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :100 mg/m3/4H/17W-ITOXIC EFFECTS :Kidney, Ureter, Bladder - other changes in urine composition
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesteraseTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :8000 ppm/8H/20W-ITOXIC EFFECTS :Peripheral Nerve and Sensation - sensory change involving peripheral nerve
Peripheral Nerve and Sensation - recording from peripheral motor nerveTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :5000 ppm/6H/90D-ITOXIC EFFECTS :Behavioral - changes in motor activity (specific assay)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - ratDOSE/DURATION :2500 ppm/6H/2Y-ITOXIC EFFECTS :Liver - changes in liver weight
Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - changes in bladder weightTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :10000 ppm/6H/11D-ITOXIC EFFECTS :Behavioral - general anesthetic
Behavioral - ataxia
Related to Chronic Data - deathTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/13W-ITOXIC EFFECTS :Behavioral - somnolence (general depressed activity)
Liver - changes in liver weight
Blood - pigmented or nucleated red blood cellsTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/13W-ITOXIC EFFECTS :Behavioral - general anesthetic
Behavioral - ataxia
Liver - changes in liver weightTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationSPECIES OBSERVED :Rodent - mouseDOSE/DURATION :5000 ppm/6H/78W-ITOXIC EFFECTS :Brain and Coverings - changes in brain weight
Liver - changes in liver weight
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :11340 mg/kgSEX/DURATION :female 45 day(s) pre-matingTOXIC EFFECTS :Reproductive - Maternal Effects - menstrual cycle changes or disordersTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :5040 mg/kgSEX/DURATION :female 1-20 day(s) after conceptionTOXIC EFFECTS :Reproductive - Fertility - litter size (e.g. # measured
before birth)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :8 gm/kgSEX/DURATION :female 6-15 day(s) after conceptionTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)TYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :32400 ug/kgSEX/DURATION :female 26 week(s) pre-matingTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetal deathTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :3500 gm/kgSEX/DURATION :multigenerationTOXIC EFFECTS :Reproductive - Fertility - mating performance (e.g. # sperm positive females
per # # copulations per # estrus cycles)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :3500 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)TYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :10000 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of total number of implants per corpora lutea)
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal deathTYPE OF TEST :TCLo - Lowest published toxic concentrationROUTE OF EXPOSURE :InhalationDOSE :7000 ppm/7HSEX/DURATION :female 1-19 day(s) after conceptionTOXIC EFFECTS :Reproductive - Specific Developmental Abnormalities - musculoskeletal systemTYPE OF TEST :TDLo - Lowest published toxic doseROUTE OF EXPOSURE :OralDOSE :6240 mg/kgSEX/DURATION :female 6-18 day(s) after conceptionTOXIC EFFECTS :Reproductive - Maternal Effects - other effectsMUTATION DATATEST SYSTEM :Rodent - ratREFERENCE :GTPZAB Gigiena Truda i Professional'nye Zabolevaniya.
Labor Hygiene and
Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)
V.1-36, . For publisher information, see MTPEEI
Volume(issue)/page/year: 25(7),33,1981
*** REVIEWS ***
ACGIH TLV-STEL 1230 mg/m3 (500 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 983 mg/m3 (400 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
(WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year: 15,223,1977
IARC Cancer Review:Human Inadequate Evidence
IMSUDL IARC Monographs, Supplement.
(WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year:
7,229,1987
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement.
(WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210)
Volume(issue)/page/year:
7,229,1987
TOXICOLOGY REVIEW
JIHTAB Journal of Industrial Hygiene and Toxicology.
(Cambridge, MA)
V.18-31, 1936-49.
For publisher information, see AEHLAU.
Volume(issue)/page/year: 20,428,1938
TOXICOLOGY REVIEW
CLCHAU Clinical Chemistry (Winston-Salem, NC).
(American Assoc. for
Clinical Chemistry, 1725 K St., NW, Washington, DC 20006)
Volume(issue)/page/year: 19,361,1973
TOXICOLOGY REVIEW
FNSCA6 Forensic Science.
(Lausanne, Switzerland)
V.1-11, 1972-78. For pub
lisher information, see FSINDR.
Volume(issue)/page/year: 2,67,1973
*** U.S. STANDARDS AND REGULATIONS ***
EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
FEREAC Federal Register.
(U.S. Government Printing Office, Supt. of
Documents, Washington, DC 20402) V.1-
Volume(issue)/page/year:
MSHA STANDARD-air:TWA 400 ppm (980 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996
Volume(issue)/page/year:
3,141,1971
OSHA PEL (Gen Indu):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Construc):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Shipyard):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
OSHA PEL (Fed Cont):8H TWA 400 ppm (980 mg/m3)
CFRGBR Code of Federal Regulations.
(U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402)
Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-AUSTRALIA:TWA 400 ppm (980 mg/m3);STEL 500 ppm (1225 mg/m3) JAN 1993
OEL-BELGIUM:TWA 400 ppm (985 mg/m3);STEL 500 ppm (1230 mg/m3) JAN 1993
OEL-DENMARK:TWA 200 ppm (490 mg/m3);Skin JAN 1993
OEL-FRANCE:STEL 400 ppm (980 mg/m3) JAN 1993
OEL-GERMANY:TWA 400 ppm (980 mg/m3) JAN 1993
OEL-JAPAN:STEL 400 ppm (980 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 400 ppm (980 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 400 ppm (980 mg/m3) JAN 1993
OEL-RUSSIA:STEL 400 ppm (10 mg/m3) JAN 1993
OEL-SWEDEN:TWA 150 ppm (350 mg/m3);STEL 250 ppm (600 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 400 ppm (980 mg/m3);STEL 800 ppm JAN 1993
OEL-TURKEY:TWA 200 ppm (500 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 400 ppm (980 mg/m3);STEL 500Skin JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO ISOPROPYL ALCOHOL-air:10H TWA 400STEL 500 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 40987
No. of Facilities: 213605 (estimated)
No. of Industries: 465
No. of Occupations: 252
No. of Employees: 3183554 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 40987
No. of Facilities: 183402 (estimated)
No. of Industries: 449
No. of Occupations: 278
No. of Employees: 4665524 (estimated)
No. of Female Employees: 2058264 (estimated)
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甲酸异丙酯
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