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The owner of this website () has banned your access based on your browser's signature (3a89faa460b07802-ua98).AbstractA comparative assay was made between crude ethanolic extratcs of Peumus boldus and Coleus barbatus in order to evaluate their relative in vitro antioxidant capacities. The antioxidant activity of boldine was employed as standard. The Q(1/2) (concentration necessary to decrease 50% of the spontaneous autoxidation of the system) indicates that Coleus barbatus (29.00 μg/mL) was almost 10 times less active than Peumus boldus (3.2 μg/mL). These results indicate the need for further investigations related to the similaraties in the folk use of the two plants in Brazil.Do you want to read the rest of this article?
CitationsCitations5ReferencesReferences0ABSTRACT: This work assessed the mechanism underlying the antisecretory gastric acid effect of Plectranthus barbatus Andrews (Lamiaceae) and active constituents. Popularly known as &false-boldo&, this plant is used in Brazilian folk medicine to treat gastrointestinal and hepatic ailments. The plant aqueous extract (AE) and isolated compounds were assayed in vivo in pylorus-ligated mice, and in vitro on acid secretion measured as [(14)C]-aminopyrine ([(14)C]-AP) accumulation in rabbit gastric glands and gastric H(+),K(+)-ATPase preparations. Injected into the duodenal lumen, the AE of the plant leaves (0.5 and 1.0 g/kg) decreased the volume (62 and 76%) and total acidity (23 and 50%) of gastric acid secretion in pylorus-ligated mice. Bioguided purification of the AE yielded an active fraction (IC(50)=24 microg/ml) that inhibited acid secretion in rabbit gastric glands with a potency 10 to 18 times greater than that of the originating extract, on both the basal and stimulated acid secretion by histamine (His) (1 microM) or bethanechol (100 microM). At the same concentrations the gastric H(+),K(+)-ATPase activity was also inhibited. The active constituent was chemically identified as the abietanoid dienedione plectrinone A which reduced the H(+),K(+)-ATPase activity with IC(50)=171 microM. The results indicate that inhibition of the gastric proton pump by this diterpenoid may account for the antisecretory acid effect and reputed anti ulcer activity of Plectranthus barbatus.Article · May 2007 +1 more author...ABSTRACT: Plectranthus barbatus andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractive target for intensive chemical and pharmacological studies up to now. This review presents data about the phytochemistry, ethnobotanical uses and pharmacology of Plectranthus barbatus as well as the pharmacology of its constituents. In addition to essential oil, abietane diterpenoids and 8,13-epoxy-labd-14-en-11-one diterpenoids are the main constituents found in Plectranthus barbatus. The major ethnobotanical uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain nervous system disorders. Forskolin as one of the major constituents with its unique adenylyl cyclase activation that underlies the wide range of pharmacological properties could explain the different traditional uses of Plectranthus barbatus. Forskolin is involved in a number of patented pharmaceutical preparations used as over-the-counter drugs for the treatment of several ailments. However, the water-insoluble nature of forskolin limits its clinical usefulness. Forskolin thus served as a prototype for the development of 6-(3-dimethylaminopropionyl)forskolin hydrochloride (NKH477) as a potent water-soluble forskolin derivative that finds use in the therapy for a number of diseases especially of the cardiovascular system.Article · Feb 2010 ABSTRACT: Plectranthus has been considered one of the richest genera in essential oils within the Lamiaceae family, which includes several species with medicinal properties. Some of them are commonly known as boldo and present taxonomic similarities and several synonymies, with antidyspeptic, analgesic and digestive actions. The aim of this study was to evaluate quantitatively and qualitatively the essential oils from P. amboinicus, P. barbatus, P. grandis and P. neochilus leaves. The oil was extracted by hydrodistillation using pentane as extracting solvent and was repeated three times for each species. The analysis of essential oil components by GC/MS in the four Plectranthus species identified 14 chemical components, mostly sesquiterpenes. High concentration of trans-caryophyllene was found in the studied oils. Some chemical components were specific for each species and other components had common occurrence in all four species, allowing their differentiation into two groups, one composed of P. amboinicus and P. neochilus and another one by P. grandis and P. barbatus. In conclusion, the four boldo species had significant differences as to essential oil yield and chemical composition. Full-text · Article · Dec 2010 +1 more author...ABSTRACT: Plectranthus barbatus Andrews (Lamiaceae) é uma planta muita utilizada na medicina popular para o tratamento de doen?as gastrointestinais e hepáticas. O objetivo do presente trabalho foi estudar o efeito protetor do extrato aquoso de P. barbatus (EAPB) sobre os danos hepáticos causados pela sobrecarga de ferro provocada pelo ferro-dextran em ratos. O tratamento com ferro-dextran induziu uma redu??o significativa na concentra??o de glutationa reduzida nos animais tratados em rela??o ao grupo controle e o tratamento prévio dos animais com o EAPB protegeu o fígado do efeito provocado pelo ferro neste par?metro. Com rela??o à lipoperoxida??o, houve aumento significativo na concentra??o de malondialdeído (MDA) nos animais tratados em rela??o ao controle, entretanto, quando os animais receberam o tratamento prévio com o EAPB, houve redu??o significativa na concentra??o do MDA. A análise histopatológica mostrou que o grupo tratado com ferro-dextran apresentou gr?nulos de ferro no citoplasma das células de Kupffer com alargamento das mesmas e algumas com os núcleos hipertróficos. O tratamento prévio com EAPB resultou no desaparecimento dos sinais de danos às células de Kupffer sem nenhum núcleo hipertrófico, mas com a presen?a de gr?nulos de ferro totalmente fagocitados, o que demonstra uma aparência morfológica normal. Portanto, o EAPB pode ser útil na preven??o de danos hepáticos induzidos por sobrecarga de ferro. Full-text · Article · Mar 2015 +1 more author...ABSTRACT: This paper describes the physicochemical composition, the evaluation of the antioxidant activity by free DPPH radicals using the scavenging method, the determination of flavonoids and total phenolic compounds of ethanol, acetone and aqueous extracts of the medicinal plant Plectranthus barbatus Andr. (Lamiaceae), dehydrated in solar dryer and circulation oven at 60 °C. Water activity rates for two drying methods were below the minimum necessary for growth and toxin production of important food pathogens. Physicochemical results showed that both processes were effective in the dehydration of P. barbatus. The results demonstrated that the acetone (over) and ethanol (over and solar dryer) extracts showed the highest content of total phenols. The ethanol extract (over) showed the highest amount of flavonoids and better antioxidant activity (75.71 ± 10.57 ug L-1). Full-text · Article · Mar 2016 +1 more author...ArticleJuly 2004 · Journal of Natural Products · Impact Factor: 3.80ArticleDecember 1949 · Comptes rendus hebdomadaires des séances de l'Académie des sciencesArticleJanuary 1992ArticleJanuary 1997Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.This publication is from a journal that may support self archiving.Advertising
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Cahiers de Nutrition et de Di&t&tiqueVol&41,&N°&3& - juin 2006pp.&139-146
CND-06--74AlimentsLa cha?ne alimentaire vecteur de polluants organiques persistants&Guido RYCHEN, Cécile DUCOULOMBIER-CR?PINEAU, Stefan JURJANZ, Luc M?JEAN, Cyril FEIDT[1]&UR <>, INRA-INPL-UHP, BP 172, 54505 Vandoeuvre lès Nancy Cedex.
Tir&s & part :
G. Rychen[2]&, à l’adresse ci-dessus.
guido.rychen@ensaia.inpl-nancy.fr
@@#100979@@L’activité agricole est en interaction avec d’autres activités anthropiques potentiellement émettrices de Polluants Organiques Persistants (POP). Ces molécules posent des problèmes de transfert dans la cha?ne alimentaire, notamment vers les produits animaux. Les POP sont caractérisés par une forte rémanence, une volatilité élevée et une lipophilicité marquée entra?nant leur accumulation potentielle dans les tissus adipeux. Ce groupe de molécules potentiellement toxiques pour l’homme et l’environnement fait l’objet d’une attention internationale. L’objectif de cette synthèse est d’aborder le devenir de trois familles de composés POP, de type hydrocarbures polycycliques : les dioxines-furanes (PCDD/F), les polychlorobiphényls (PCB) et les hydrocarbures aromatiques polycycliques (HAP). Les résultats de recherche montrent une contamination significative des fourrages situés en zones exposées aux polluants par comparaison avec des zones isolées. Ils mettent également en évidence un transfert différentiel de ces molécules toxiques vers les matrices biologiques dont le lait.
AbstractHuman activities produce polluting compounds such as the Persistent Organic Pollutants group (POPs) which may interact with agriculture. These molecules raised concern about risk of transfer through the food chain via the animal product. The POPs are characterised by a strong persistence in the environment, a high volatility and a lipophilicity which lead to their accumulation in fat tissues. These compounds are enlisted in international conventions to organise the information about their potential toxicity for humans and the environment. The aim of this paper is to study transfer in the food chain of three groups of POPs: the dioxins-furans (PCDD/F), the polychlorobiphenyls (PCB) and the Polycyclic Aromatic Hydrocarbons (PAH). The results show that the contamination of fodder by these compounds is observed when they are exposed to emission sources compared to remote areas. They also show that a differential transfer of the molecules is detected towards biological matrices (milk).
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- & 2006 Elsevier Masson SAS. Tous droits r&serv&s.
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