Curriculum Vitae
&Yao Chang, Ph.D.
Address:&&&&&&&&&&&
No. 367, Sheng-Li Road, Tainan 70456, Taiwan
&&&&&&&&&&&&&&&&&&&&&&&&&& Phone:
886-6-2083422 ext. 65261
&&&&&&&&&&&&&&&&&&&&&&&&&& E-mail:
Professional history:
2012-presnce&&&&& Adjunct Associate Professor, Department of
Microbiology and Immunology, College of Medicine, National Cheng Kung
University, Tainan, Taiwan
2011-presnce&&&&& Associate Investigator, National Institute
of Infectious Diseases and Vaccinology, National Health Research Institutes,
Tainan, Taiwan
2009-present&&&&& Adjunct Assistant Professor, Graduate
Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung
University, Tainan, Taiwan
&&&&&&&&& Adjunct Assistant Professor, Department of
Microbiology and Immunology,
&&&&&&&&& Assistant Investigator, Division of
Clinical Research/ Infectious Diseases, National Health Research Institutes,
Tainan, Taiwan
&&&&&&&&& Postdoctoral fellow, Graduate Institute of
Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
&&&&&&&& Ph.D., Graduate Institute of Microbiology,
College of Medicine, National Taiwan University, Taipei, Taiwan
&&&&&&&&& B.Sc., Department of Zoology, Zoology
Division, College of Science, National Taiwan University, Taipei, Taiwan
Honors and Awards:
Research Funding for Excellent Junior Scholars, supported by Ministry of
Science and Technology
2012&&&&&&& Research Achievement Award for Junior Research
Investigators, National Health Research Institutes
2001&&&&&&& National Health Research
Institutes Postdoctoral
Fellowship Award
2001&&&&&&& Outstanding
Publication Award for Graduate Students of College of Medicine, National Taiwan
University
2000&&&&&&& Honorary Member of the Phi Tau Phi Scholastic
Honor Society at National Taiwan University
1995&&&&&&& Professor Chih-Chung Yenˇs
Scholarship Award of Chinese Society of Microbiology
Expert fields:
Virology (Epstein-Barr virus infection, reactivation and
pathogenesis)
Oncology (molecular mechanisms of nasopharyngeal carcinoma
development)
Cell biology (cell
differentiation and inflammation)
Research projects:
Regulation of EBV latent membrane proteins and its application to related cancer
immunotherapy
&&&&&& Molecular and functional interaction between
Epstein-Barr virus and a tumor suppressor protein WOX1
&&&&&& Immunoregulatory and oncogenic effects of
Epstein-Barr virus reactivation in its associated malignancies
&&&&&& Inflammatory responses and cytokine
production affected by A/H1N1 and other influenza A viruses
&&&&&& Pathologic significance of endoplasmic
reticulum stress in nasopharyngeal carcinoma: induction of the Epstein-Barr
virus oncoprotein LMP1
&&&&&& Contribution of Epstein-Barr Virus
Reactivation to Inflammatory Events of the Associated Cancers
&&&&&& Molecular Mechanisms of Gene Transactivation
Mediated by Epstein-Barr Virus Zta and Rta Proteins
Publications: (*corresponding
Yao Chang*,
Yu-Yan Lan, Jenn-Ren Hsiao, and Nan-Shan Chang (Mar. 2015). Strategies of
oncogenic microbes to deal with WW domain-containing oxidoreductase.
Experimental Biology and Medicine
(Maywood), 240(3):329-337. doi:10..
Qiao Jing Lew, Kai Ling Chu,
Yi Ling Chia, Benjamin Soo, Jia Pei Ho, Chew Har Ng, Hui Si Kwok, Cheng-Ming
Chiang, Yao Chang, and
Sheng-Hao Chao (Jan. 2015). GCN5 inhibits XBP-1S-mediated transcription by
antagonizing PCAF action. Oncotarget,
6(1):271-287.
Chih-Yeu Fang, Chung-Chun Wu,
Hui-Yu Hsu, Hsin-Ying Chuang, Sheng-Yen Huang, Ching-Hwa Tsai,
Yao Chang, George Sai-Wah Tsao,
Chi-Long Chen, and Jen-Yang Chen (Jan. 2015). EGCG inhibits proliferation,
invasiveness and tumor growth by upregulation of adhesion molecules, suppression
of gelatinases activity, and induction of apoptosis in nasopharyngeal carcinoma
cells. International Journal of Molecular
Sciences, 16(2):. doi:10.3390/ijms.
Kung-Chao Chang,
Yao Chang, Lily Hui-Ching
Wang, Hung-Wen Tsai, Wenya Huang, and Ih-Jen Su (Sep. 2014). Pathogenesis of
viruses-associated human cancers: Epstein-Barr virus and hepatitis B virus as
two examples. Journal of the Formosan
Medical Association, 113(9):581-590. doi:10.1016/j.jfma..
Chung-Chun Wu, Shin-Ying
Chuang, Chao-Yi Lin, Yen-Ju Chen, Wan-Hua Tsai, Chih-Yeu Fang, Sheng-Yen Huang,
Fu-Yang Chuang, Su-Fang Lin, Yao Chang,
and Jen-Yang Chen (Dec. 2013). Inhibition of Epstein-Barr virus reactivation in
nasopharyngeal carcinoma cells by dietary sulforaphane.
Molecular Carcinogenesis, 52(12):946-958. doi:10.1002/mc.21926.
Kung-Chao Chang, Wei-Chao
Chang, Yao Chang, Liang-Yi
Hung, Chien-Hsien Lai, Yu-Min Yeh, Yu-Wei Chou, and Chung-Hsuan Chen (Nov.
2013). Ran GTPase-activating protein 1 is a therapeutic target in diffuse large
B-cell lymphoma. PLoS ONE,
8(11):e79863. doi:10.1371/journal.pone.0079863
Yu-Wei Hsiao, Chien-Feng Li,
Jhih-Ying Chi, Joseph T. Tseng, Yao
Chang, Li-Jin Hsu, Chien-Hsun Lee, Tsung-Hao Chang, Shao-Ming Wang,
Dennis Ding Hwa Wang, Hung-Chi Cheng, and Ju-Ming Wang (Jul. 2013).
CCAAT/enhancer binding protein ? in macrophages contributes to immunosuppression
and inhibits phagocytosis in nasopharyngeal carcinoma.
Science Signaling, 6(284):ra59.
doi:10.1126/scisignal.2003648.
Yu-Yan Lan, Shih-Yi Wu, Hsiao-Ching
Lai, Nan-Shan Chang, Fang-Hsin Chang, Meng-Hsuan Tsai, Ih-Jen Su, and
Yao Chang*
(Jul. 2013). WW domain-containing oxidoreductase is involved in upregulation of
matrix metalloproteinase 9 by Epstein-Barr virus latent membrane protein 2A.
Biochemical and Biophysical Research
Communications, 436(4):672-676. doi:10.1016/j.bbrc..
Hsin-Wei Chen, Hsin-Yu Chen,
Li-Tzu Wang, Fu-Hui Wang, Li-Wen Fang, Hsiu-Yu Lai, Hsuan-Hsu Chen, Jean Lu,
Ming-Shiu Hung, Yao Chang,
Mei-Yu Chen, Shih-Jen Liu, Pele Chong, Oscar Kuang-Sheng Lee, and Shu-Ching Hsu
(May 2013). Mesenchymal stem cells tune the development of monocyte-derived
dendritic cells toward a myeloid-derived suppressive phenotype through
growth-regulated oncogene chemokines.
Journal of Immunology, 190(10):. doi:10.4049/​jimmunol.1202775.
Yu-Yan Lan, Tzu-Hao Yeh,
Wei-Hung Lin, Shih-Yi Wu, Hsiao-Ching Lai, Fang-Hsin
Chang, Kenzo Takada, and
Yao Chang*
(Feb. 2013). Epstein-Barr virus Zta upregulates matrix metalloproteinases 3 and
9 that synergistically promote cell invasion in vitro.
PLoS ONE, 8(2):e56121.
doi:10.1371/journal.pone.0056121.
Chih-Yeu Fang, Sheng-Yen
Huang, Chung-Chun Wu, Hui-Yu Hsu, Sheng-Ping Chou, Ching-Hwa Tsai,
Yao Chang, Kenzo Takada, and
Jen-Yang Chen (Sep. 2012). The synergistic effect of chemical carcinogens
enhances Epstein-Barr virus reactivation and tumor progression of nasopharyngeal
carcinoma cells. PLoS ONE,
7(9):e44810. doi:10.1371/journal.pone.0044810.
Yu-Yan Lan, Jenn-Ren Hsiao,
Kung-Chao Chang, Jeffrey Shu-Ming
Chang, Chaio-Wei Chen, Hsiao-Ching Lai, Shih-Yi Wu, Tzu-Hao Yeh, Fang-Hsin
Chang, Wei-Hung
Su, and Yao Chang*
(Jun. 2012). Epstein-Barr virus latent membrane protein 2A
promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated
induction of matrix metalloproteinase 9.
Journal of Virology, 86(12):. doi:10.1128/JVI.00174-12.
Chien-Hsun Lee, Tzu-Hao Yeh,
Hsiao-Ching Lai, Shih-Yi Wu, Ih-Jen Su, Kenzo Takada, and
Yao Chang*
(Jul. 2011). Epstein-Barr virus Zta-induced immunomodulators from nasopharyngeal
carcinoma cells upregulate interleukin-10 production from monocytes.
Journal of Virology, 85(14):.
doi:10.1128/JVI.00182-11.
Cheng-Chih Huang, Jenn-Ren
Hsiao, Ming-Wei Yang, Yuan-Hua Wu, Keng-Fu Hsu,
Yao Chang, Chaio-Wei Chen,
Sen-Tien Tsai, Hsuan-Pei Wei, and Ying-Tai Jin (Jul. 2011). Human papilloma
virus detection in neoplastic and non-neoplastic nasopharyngeal tissues in
Taiwan. Journal of Clinical Pathology,
64(7):571-577. doi:10.1136/jcp..
Ying-Fan Chen, Chao-Ling Tung,
Yao Chang, Wen-Chi Hsiao, Ih-Jen
Su, and Sunny Sun (Apr. 2011). Analysis of global methylation using a Zta-expressing
nasopharyngeal carcinoma cell line.
Genomics, 97(4):205-213. doi:10.1016/j.ygeno..
Kung-Chao Chang, Paul
Chih-Hsueh Chen, Ya-Ping Chen,
Chang, and Ih-Jen Su (Jan. 2011). Dominant expression of survival
signals of endoplasmic reticulum stress response in Hodgkin lymphoma.
Cancer Science, 102(1):275-281.
doi:10.1111/j.10.01765.x.
Sheng-Yen Huang, Chih-Yeu
Fang, Ching-Hwa Tsai, Yao
Chang, Kenzo Takada, Tsuey-Ying Hsu, and Jen-Yang Chen (Dec. 2010).
N-methyl-Nˇ-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium
butyrate to enhance Epstein-Barr virus reactivation and genome instability in
nasopharyngeal carcinoma cells. Chemico-Biological
Interactions, 188(3):623-634. doi:10.1016/j.cbi..
Mei-Chi Hsu, Jenn-Ren Hsiao,
Kung-Chao Chang, Yuan-Hua Wu, Ih-Jen Su, Ying-Tai Jin, and
(Oct. 2010). Increase of programmed death-1-expressing intratumoral CD8 T cells
predicts a poor prognosis for nasopharyngeal carcinoma.
Modern Pathology, 23(10):.
doi:10.1038/modpathol..
Hsiao-Ching Lai, Jenn-Ren
Hsiao, Chaio-Wei Chen, Shih-Yi Wu, Chien-Hsun Lee, Ih-Jen Su, Kenzo Takada, and Yao
(Sep. 2010). Endogenous latent membrane protein 1 in
Epstein-Barr virus-infected nasopharyngeal carcinoma cells attracts T
lymphocytes through upregulation of multiple chemokines.
Virology, 405(2):464-473. doi:10.1016/j.virol..
Jiin-Tarng Wang, Yu-Chia
Chuang, Kun-Liang Chen, Chih-Chung Lu, Shin-Lian Doong, Hsu-Hsiang Cheng, Ya-Ling
Chen, Ting-Yun Liu, Yao Chang,
Chia-Hung Han, Sheng-Wen Yeh, and Mei-Ru Chen (Sep. 2010). Characterization of
Epstein-Barr virus BGLF4 kinase expression control at the transcriptional and
translational levels. Journal of General
Virology, 91(9):. doi:10.1099/vir.0..
Jenn-Ren Hsiao,
Yao Chang#,
Yuh-Ling Chen, Su-Huei Hsieh, Keng-Fu Hsu, Chun-Fu Wang, Sen-Tien Tsai, and
Ying-Tai Jin (Feb. 2010).
Cyclic ?v?6-targeting peptide selected from biopanning with clinical potential
for head and neck squamous cell carcinoma.
Head & Neck, 32(2):160-172.
doi:10.1002/hed.21166.
Wen-Chuan Hsieh, Bau-Shin Lan,
Yi-Ling Chen, Yao
Chang, Huai-Chia Chuang, and Ih-Jen Su (Feb. 2010). Efficacy of
peroxisome proliferator activated receptor agonist in the treatment of
virus-associated haemophagocytic syndrome in a rabbit model.
Antiviral Therapy, 15(1):71-81.
doi:10.3851/IMP1490.
Kung-Chao Chang,
Chang, Dan Jones, and Ih-Jen Su (Jul. 2009). Aberrant expression of
cyclin A correlates with morphogenesis of Reed-Sternberg cells in Hodgkin
lymphoma. American Journal of Clinical
Pathology, 132(1):50-59. doi:10.1309/AJCPBDFR5L5UOAUZ.
Jenn-Ren Hsiao, Kung-Chao
Chang, Chaio-Wei Chen, Shih-Yi Wu, Ih-Jen Su, Mei-Chi Hsu, Ying-Tai Jin,
Sen-Tien Tsai, Kenzo Takada, and Yao
(May 2009). Endoplasmic reticulum stress triggers
XBP-1-mediated up-regulation of an EBV oncoprotein in nasopharyngeal carcinoma.
Cancer Research, 69(10):.
doi:10.72.CAN-09-0277.
Chih-Yeu Fang, Chia-Huei Lee,
Chung-Chun Wu, Yu-Ting Chang, Shu-Ling Yu, Sheng-Ping Chou, Ping-Ting Huang,
Chi-Long Chen, Jia-Woei Hou, Yao Chang,
Ching-Hwa Tsai, Kenzo Takada, and Jen-Yang Chen (May 2009). Recurrent chemical
reactivations of EBV promotes genome instability and enhances tumor progression
of nasopharyngeal carcinoma cells.
International Journal of Cancer, 124(9):. doi:10.1002/ijc.24179.
Chung-Pei Lee, Yu-Hao Huang,
Su-Fang Lin, Yao
Chang, Yu-Hsin Chang, Kenzo Takada, and Mei-Ru Chen (Dec. 2008).
Epstein-Barr virus BGLF4 kinase induces disassembly of the nuclear lamina to
facilitate virion production. Journal of Virology, 82(23):. doi:10.1128/JVI.01100-08.
Huai-Chia Chuang, Ju-Ming
Wang, Wen-Chuan Hsieh, Yao
Chang, and Ih-Jen Su (Nov. 2008). Up-regulation of activating
transcription factor-5 suppresses SAP expression to activate T cells in
hemophagocytic syndrome associated with Epstein-Barr virus infection and immune
disorders. American Journal of Pathology,
173(5):. doi:10.2353/ajpath..
Chia-Huei Lee, Chih-Yeu Fang,
Jim Jinn-Chyuan Sheu, Yao
Chang, Kenzo Takada, and Jen-Yang Chen (Aug. 2008). Amplicons on
chromosome 3 contain oncogenes induced by recurrent exposure to 12-O-tetradecanoylphorbol-13-acetate
and sodium n-butyrate and Epstein-Barr
virus reactivation in a nasopharyngeal carcinoma cell line.
Cancer Genetics and Cytogenetics,
185(1):1-10. doi:10.1016/j.cancergencyto..
Meichi Hsu, Shih-Yi Wu,
Shih-Shin Chang, Ih-Jen Su, Ching-Hwa Tsai, Siao-Jing Lai, Ai-Li Shiau, Kenzo
Takada, and Yao
(Apr. 2008). Epstein-Barr virus lytic transactivator Zta enhances chemotactic
activity through induction of interleukin-8 in nasopharyngeal carcinoma cells.
Journal of Virology, 82(7):.
doi:10.1128/JVI.02301-07.
Wen-Chuan Hsieh,
Chang, Mei-Chi Hsu, Guan-Chung Hsiao, Huai-Chia Chuang, and Ih-Jen Su
(May 2007). Emergence of anti-red blood cell antibodies triggers red cell
phagocytosis by activated macrophages in a rabbit model of Epstein-Barr
virus-associated hemophagocytic syndrome.
American Journal of Pathology, 170(5):.
doi:10.2353/ajpath..
Huai-Chia Chuang, Jong-Ding
Lay, Shuang-En Chuang, Wen-Chuan Hsieh, Yao
Chang, and Ih-Jen Su (May 2007). Epstein-Barr virus (EBV) latent
membrane protein-1 down-regulates tumor necrosis factor-a
receptor-1 and confers resistance to TNF-a-induced
apoptosis in T cells: implication for the progression to T-cell lymphoma in
EBV-associated hemophagocytic syndrome.
American Journal of Pathology, 170(5):. doi:
10.2353/ajpath..
Yao Chang,
Heng-Huan Lee, Yu-Te Chen, Jean Lu, Shih-Yi Wu, Chaio-Wei Chen, Kenzo Takada,
and Ching-Hwa Tsai (Aug. 2006). Induction of the early growth response-1 gene by
Epstein-Barr virus lytic transactivator Zta.
Journal of Virology, 80(15):. doi:10.1128/JVI.02608-05.
Huai-Chia Chuang, Jong-Ding
Lay, Wen-Chuan Hsieh, Hui-Ching Wang, Yao
Chang, Shuang-En Chuang, and Ih-Jen Su (Nov. 2005). Epstein-Barr virus
LMP1 inhibits the expression of SAP gene and upregulates Th1 cytokines in the
pathogenesis of hemophagocytic syndrome.
Blood, 106(9):. doi:10.1182/blood-6.
Yao Chang,
Tso-Ching Lee, Jian-Chiuan Li, Ting-Lung Lai, Huey-Huey Chua, Chi-Long Chen,
Shin-Lian Doong, Chen-Kung Chou, Tzung-Shiahn Sheen,
and Ching-Hwa Tsai (Oct. 2005). Differential expression of osteoblast-specific
factor 2 and polymeric immunoglobulin receptor genes in nasopharyngeal
carcinoma. Head & Neck,
27(10):873-882. doi:10.1002/hed.20253.
Tsuey-Ying Hsu,
Yao Chang, Pei-Wen Wang,
Mei-Ying Liu, Mei-Ru Chen, Jen-Yang Chen, and Ching-Hwa Tsai (Feb. 2005).
Reactivation of Epstein-Barr virus can be triggered by an Rta protein mutated at
the nuclear localization signal. Journal of General Virology, 86(2):317-322.
doi:10.1099/vir.0.80556-0.
Yao Chang,
Heng-Huan Lee, Shih-Shin Chang, Tsuey-Ying Hsu,
Pei-Wen Wang, Yu-Sun Chang,
Kenzo Takada, and
Ching-Hwa Tsai (Dec. 2004). Induction of Epstein-Barr virus latent membrane
protein 1 by a lytic transactivator Rta.
Journal of Virology, 78(23):.
doi:10.1128/JVI.78.23..2004.
Yao Chang,
Shih-Shin Chang, Heng-Huan Lee, Shin-Lian Doong,
Kenzo Takada, and
Ching-Hwa Tsai (Jun. 2004). Inhibition of the Epstein-Barr
virus lytic cycle by Zta-targeted RNA interference.
Journal of General Virology,
85(6):. doi:10.1099/vir.0.79886-0.
Yao Chang, Sou-De
Cheng, and Ching-Hwa Tsai (Feb, 2002). Chromosomal integration of Epstein-Barr
virus genomes in nasopharyngeal carcinoma cells.
Head & Neck, 24(2):143-150. doi:10.1002/hed.10039.
Lu, Shao-Yin Chen, Huey-Huey Chua, Yu-Sheng Liu, Yu-Tzu
Huang, Yao
Chang, Jen-Yang Chen, Tzung-Shiahn Sheen, and Ching-Hwa Tsai (Aug.
2000). Upregulation of TKT tyrosine kinase by the Epstein-Barr virus
transactivator Zta. Journal of Virology,
Yao Chang, Che-Huang
Tung, Yu-Tzu Huang, Jean Lu, Jen-Yang Chen, and Ching-Hwa Tsai (Oct. 1999).
Requirement for cell-to-cell contact in Epstein-Barr virus infection of
nasopharyngeal carcinoma cells and keratinocytes.
Journal of Virology, 73(10):.
Yu-Tzu Huang, Tzung-Shiahn
Sheen, Chi-Long Chen, Jean Lu, Yao
Chang, Jen-Yang Chen, and Ching-Hwa Tsai (Apr. 1999). Profile of
cytokine expression in nasopharyngeal carcinomas: a distinct expression of
interleukin-1 in tumor and CD4+ T cells.
Cancer Research, 59(7):.
Tzung-Shiahn Sheen, Jeng-Yuh
Ko, Yen-Liang Chang, Yuan-Shau Chang, Yu-Tzu Huang,
Yao Chang, Ching-Hwa Tsai, and Mow-Ming Hsu (Dec. 1998).
Nasopharyngeal swab and PCR for the screening of nasopharyngeal carcinoma in
endemic area: a good supplement to the serologic screening.
Head & Neck, 20(8):732-738.
Chang, Tzung-Shiahn Sheen, Jean Lu, Yu-Tzu
Huang, Jen-Yang Chen, Czau-Siung Yang, and Ching-Hwa Tsai (Jun. 1998). Detection
of transcripts initiated from two viral promoters (Cp and Wp) in Epstein-Barr
virus-infected nasopharyngeal carcinoma cells and biopsies.
Laboratory Investigation,
78(6):715-726.
Books/chapters:
Ih-Jen Su,
Yao Chang, Grace Yu, and Charles Dwo-Yuan Sia (2013). Viruses
and human cancers: pathogenesis and therapeutic implication. Chapter 6, p.
56-67. Principles of Molecular Diagnostics
and Personalized Cancer Medicine, edited by Dongfeng Tan and Henry T. Lynch,
published by Lippincott Williams & Wilkins, Philadelphia, PA.
Presentations: (*oral
presentation)
Yao Chang*,
Yu-Yan Lan, Tzu-Hao Yeh, Fang-Hsin Chang, Hsiao-Ching Lai, Shih-Yi Wu, and Ih-Jen
Su (Jun. 2013). Multiple ways of Epstein-Barr virus to induce matrix
metalloproteinases and to promote cell invasion. 6th International
Symposium on Nasopharyngeal Carcinoma. İstanbul, Turkey.
Yao Chang, Mei-Chi Hsu, Jenn-Ren Hsiao, Kung-Chao Chang, and Ih-Jen Su (May 2013).
Expression of programmed death-1 is increased in CD8+ tumor-infiltrating
lymphocytes of nasopharyngeal carcinoma. Annual Meeting and International
Conference of Taiwan Head and Neck Society. Tainan, Taiwan.
Yao Chang*
(Nov. 2012). Matrix metalloproteinase 9 is a convergent effector for EBV-induced cell
invasion. Asia-Pacific Congress on Virus Related Malignancies. Taipei, Taiwan.
Yao Chang*,
Chien-Hsun Lee, Tzu-Hao Yeh, Hsiao-Ching Lai, Shih-Yi Wu, and Ih-Jen Su (Jun.
2011). Potential roles of Epstein-Barr virus reactivation in local immune
suppression of nasopharyngeal carcinoma. 5th
International Symposium on Nasopharyngeal Carcinoma.
Penang, Malaysia.
(May 2011). Effects of Epstein-Barr virus on the tumor microenvironment of
nasopharyngeal carcinoma. The 8th Across the
Taiwan Strait
Symposium on Cell Biology. Tainan,
(Dec. 2010).
Interaction among Epstein-Barr virus, tumor cells and immune cells in cancer
development. NHRI-NTHU Joint Research Conference.
Chien-Hsun Lee, Tzu-Hao Yeh,
Hsiao-Ching Lai, Shih-Yi Wu, and
Chang (Sep. 2010). A novel way of EBV to upregulate production of human
interleukin-10. 14th Biennial Conference of the International
Association for Research on Epstein-Barr Virus and Associated Diseases.
Birmingham,
Mei-Chi Hsu,
Jenn-Ren Hsiao, Chaio-Wei Chen, and Yao
(Jun. 2009). Association of an immunosuppressive marker with prognosis of
nasopharyngeal carcinoma. 4th International Symposium on
Nasopharyngeal Carcinoma. Marrakech,
Jenn-Ren Hsiao, Chaio-Wei Chen, Shih-Yi Wu, Mei-Chi Hsu, and Ih-Jen Su (Nov.
2008). Induction of Epstein-Barr virus latent membrane protein 1 by endoplasmic
reticulum stress in nasopharyngeal carcinoma cells. 13th Biennial
Conference of the International Association for Research on Epstein-Barr Virus
and Associated Diseases. Guangzhou, China.
(Jul. 2007). Upregulation of interleukin-8 by Epstein-Barr virus lytic
transactivator Zta in nasopharyngeal carcinoma cells. East-West Symposium on
Nasopharyngeal Carcinoma.
Sunshine Coast, Australia.
(May 2007). Regulation of cellular genes by Epstein-Barr virus lytic
transactivator Zta. Conference of Advanced Virus Research in
University.
Hualien, Taiwan.
Chang, Yu-Te Chen, Heng-Huan Lee, Shih-Yi Wu,
Chaio-Wei Chen, and Ching-Hwa Tsai (Jul. 2006). Inter-regulation of Zta, Rta,
and Egr-1 as a positive-feedback network in spontaneous reactivation of
Epstein-Barr virus. 12th Biennial Conference of the International
Association for Research on Epstein-Barr Virus and Associated Diseases.
Yu-Te Chen, Heng-Huan Lee, Shih-Yi Wu, Chaio-Wei Chen, and Ching-Hwa Tsai (May
2006). Early growth response-1 gene is induced by Zta and involved in
reactivation of Epstein-Barr virus. 6th NHRI
Conference on Tumor-Associated Herpesviruses. Miaoli, Taiwan.
Chang, Yu-Te Chen, Heng-Huan Lee, Shih-Shin
Chang, and Ching-Hwa Tsai. (Apr. 2005). Epstein-Barr virus Zta-mediated
induction of Egr-1 gene. The NHRI 10th Anniversary and Campus Grand
Opening. Miaoli,
Heng-Huan Lee, Shih-Shin Chang, and Ching-Hwa Tsai (Sep. 2004).
Induction of latent membrane protein 1 during Epstein-Barr virus reactivation.
11th Biennial Conference of the International Association for
Research on Epstein-Barr Virus and Associated Diseases. Regensburg, Germany.
Chang*, Heng-Huan Lee,
Shih-Shin Chang,
Tsuey-Ying Hsu, and
Ching-Hwa Tsai (Jun. 2004). Rta-mediated induction of
Epstein-Barr virus latent membrane protein 1. 5th
NHRI Conference on Tumor-Associated Herpesviruses.
Taoyuan, Taiwan.
Chang, Jian-Chiuan Li, Ting-Lung Lai,
Huey-Huey Chua, Jen-Yang Chen, and Ching-Hwa Tsai (Jul. 2002). Identification of
two cellular genes differentially expressed in nasopharyngeal carcinoma
biopsies. 10th International Symposium on Epstein-Barr Virus and
Associated Malignant Diseases. Cairns,
Australia.
Yao Chang Personal}